Transcriptomics and epigenomics of rat born to dams fed a diet deficient in methyl group donors
Ontology highlight
ABSTRACT:
ORGANISM(S): Rattus norvegicus
SUBMITTER: Sebastien Hergalant
PROVIDER: E-GEOD-60775 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Identification of master genes involved in liver key functions through transcriptomics and epigenomics of methyl donor deficiency in rat: relevance to nonalcoholic liver disease.
Chen Gaili G Broséus Julien J Hergalant Sébastien S Donnart Audrey A Chevalier Catherine C Bolaños-Jiménez Francisco F Guéant Jean-Louis JL Houlgatte Rémi R
Molecular nutrition & food research 20141209 2
<h4>Scope</h4>Our study aims to investigate molecular events associated to methyl donor deficiency (MDD) by analyzing the transcriptome and the methylome of MDD rats in liver.<h4>Methods and results</h4>Twenty-one-day-old rats born to mothers fed either with a standard diet or a MDD diet during gestation and lactation were compared. From a total of 44 000 probes for 26 456 genes, we found two gene clusters in MDD rats whose expression levels had significant differences compared with controls: 32 ...[more]
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