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Transcription profiling of rat mammary tumors with varying invasive phenotyes

ABSTRACT: We used microarrays to identify genes implicated in breast cancer progression Experiment Overall Design: By serially transplanting initial carcinogen induced rat mammary tumors (PR for primary tumor) through five generations of syngeneic hosts, we generated a series of tumors (T1 through T5) with varying invasive and metastatic phenoytpes

ORGANISM(S): Rattus norvegicus

SUBMITTER: Penelope Lyn Miron

PROVIDER: E-GEOD-6093 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Serial transplantation of NMU-induced rat mammary tumors: a model of human breast cancer progression.

Chan Maren M MM Lu Xin X Merchant Faisal M FM Iglehart James Dirk JD Miron Penelope L PL

International journal of cancer 20070801 3

Human breast cancer is a heterogeneous disease that appears to progress from an in situ tumor to invasive cancer. Little is known about the molecular events driving this progression. Although microarray technology has helped us understand the genetic heterogeneity of breast cancer, its application to studying the transition from in situ to invasive disease is limited by the inability to follow the progression of a single patient's tumor. We previously used rat specific microarrays to show that N ...[more]

PMID: 17405122

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