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Obesity accelerates epigenetic aging of human liver

ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Homo sapiens

SUBMITTER: Steve Horvath

PROVIDER: E-GEOD-61256 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Obesity accelerates epigenetic aging of human liver.

Horvath Steve S Erhart Wiebke W Brosch Mario M Ammerpohl Ole O von Schönfels Witigo W Ahrens Markus M Heits Nils N Bell Jordana T JT Tsai Pei-Chien PC Spector Tim D TD Deloukas Panos P Siebert Reiner R Sipos Bence B Becker Thomas T Röcken Christoph C Schafmayer Clemens C Hampe Jochen J

Proceedings of the National Academy of Sciences of the United States of America 20141013 43

Because of the dearth of biomarkers of aging, it has been difficult to test the hypothesis that obesity increases tissue age. Here we use a novel epigenetic biomarker of aging (referred to as an "epigenetic clock") to study the relationship between high body mass index (BMI) and the DNA methylation ages of human blood, liver, muscle, and adipose tissue. A significant correlation between BMI and epigenetic age acceleration could only be observed for liver (r = 0.42, P = 6.8 × 10(-4) in dataset 1 ...[more]

PMID: 25313081

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