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Global gene expression profiling of FOP- or resFOP-iMSCs treated by several ligands

ABSTRACT: Analyzed differentially expressed genes among FOP- or resFOP-iMSCs treated by several ligands: Activin-A, 100 ng/mL; BMP-7, 100 ng/mL; TGF-B3, 10 ng/mL Comparison of gene expressions among FOP- or resFOP-iMSCs treated 16h by several ligands

ORGANISM(S): Homo sapiens

SUBMITTER: Makoto Ikeya

PROVIDER: E-GEOD-62783 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Neofunction of ACVR1 in fibrodysplasia ossificans progressiva.

Hino Kyosuke K Ikeya Makoto M Horigome Kazuhiko K Matsumoto Yoshihisa Y Ebise Hayao H Nishio Megumi M Sekiguchi Kazuya K Shibata Mitsuaki M Nagata Sanae S Matsuda Shuichi S Toguchida Junya J

Proceedings of the National Academy of Sciences of the United States of America 20151130 50

Fibrodysplasia ossificans progressiva (FOP) is a rare genetic disease characterized by extraskeletal bone formation through endochondral ossification. FOP patients harbor point mutations in ACVR1 (also known as ALK2), a type I receptor for bone morphogenetic protein (BMP). Two mechanisms of mutated ACVR1 (FOP-ACVR1) have been proposed: ligand-independent constitutive activity and ligand-dependent hyperactivity in BMP signaling. Here, by using FOP patient-derived induced pluripotent stem cells (F ...[more]

PMID: 26621707

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Global gene expression profiling of FOP- or resFOP-iMSCs after chondrogenic differentiation

Project description:Comparison of gene expressions among FOP- or resFOP-iMSCs after chondrogenic differentiation with or without Activin-A. Comparison of gene expressions among FOP- or resFOP-iMSCs after chondrogenic differentiation with or without Activin-A.

2015-12-09 | E-GEOD-69459 | biostudies-arrayexpress

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