Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of human mesenchymal stromal cells to reveal senescence associated gene expression changes

ABSTRACT: Transcription profiling of human mesenchymal cells (MSCs) after ex vivo expansion under culture conditions supporting extensive cell proliferation. Highly efficient cell expansion within short time (~40 days) and comparison of gene expression profiles from MSCs after primary seeding, defined as early passage versus MSCs after a minimum of 17 (max 34) population doublings, defined as late passage. Combined data of passage 1 and 2 was compared to passage 0 (zero) as reference

ORGANISM(S): Homo sapiens

SUBMITTER: Christian Guelly 

PROVIDER: E-MEXP-1997 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Replicative senescence-associated gene expression changes in mesenchymal stromal cells are similar under different culture conditions.

Schallmoser Katharina K   Bartmann Christina C   Rohde Eva E   Bork Simone S   Guelly Christian C   Obenauf Anna C AC   Reinisch Andreas A   Horn Patrick P   Ho Anthony D AD   Strunk Dirk D   Wagner Wolfgang W  

Haematologica 20100106 6

<h4>Background</h4>Research on mesenchymal stromal cells has created high expectations for a variety of therapeutic applications. Extensive propagation to yield enough mesenchymal stromal cells for therapy may result in replicative senescence and thus hamper long-term functionality in vivo. Highly variable proliferation rates of mesenchymal stromal cells in the course of long-term expansions under varying culture conditions may already indicate different propensity for cellular senescence. We hy  ...[more]

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