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P53 and ATF4 Mediate Distinct and Additive Mechanisms to Skeletal Muscle Atrophy During Limb Immobilization

ABSTRACT: p53 regulates a distinct subset of skeletal muscle mRNAs during immobilization-induced skeletal muscle atrophy For additional details see Fox et al, p53 and ATF4 mediate distinct and additive pathways to skeletal muscle atrophy during limb immobilization. Am J Physiol Endocrinol Metab. 2014 Aug 1;307(3):E245-61. Bilateral tibialis anterior muscles were harvested at three days for the following conditions: 1) hindlimb immobilization of C57BL/6 mice; 2) hindlimb immobilization of p53 mKO and littermate control mice; 3) transfection of wild type mice with p53 plasmid or control plasmid

ORGANISM(S): Mus musculus

SUBMITTER: Daniel Fox

PROVIDER: E-GEOD-62897 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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p53 and ATF4 mediate distinct and additive pathways to skeletal muscle atrophy during limb immobilization.

Fox Daniel K DK Ebert Scott M SM Bongers Kale S KS Dyle Michael C MC Bullard Steven A SA Dierdorff Jason M JM Kunkel Steven D SD Adams Christopher M CM

American journal of physiology. Endocrinology and metabolism 20140603 3

Immobilization causes skeletal muscle atrophy via complex signaling pathways that are not well understood. To better understand these pathways, we investigated the roles of p53 and ATF4, two transcription factors that mediate adaptations to a variety of cellular stresses. Using mouse models, we demonstrate that 3 days of muscle immobilization induces muscle atrophy and increases expression of p53 and ATF4. Furthermore, muscle fibers lacking p53 or ATF4 are partially resistant to immobilization-i ...[more]

PMID: 24895282

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p53 and ATF4 Mediate Distinct and Additive Mechanisms to Skeletal Muscle Atrophy During Limb Immobilization

Project description:p53 regulates a distinct subset of skeletal muscle mRNAs during immobilization-induced skeletal muscle atrophy For additional details see Fox et al, p53 and ATF4 mediate distinct and additive pathways to skeletal muscle atrophy during limb immobilization. Am J Physiol Endocrinol Metab. 2014 Aug 1;307(3):E245-61.

2014-11-05 | GSE62897 | GEO

Low responders to endurance training exhibit greater atrophy

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Muscle unloading and reloading

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Effect of spermine oxidase overexpression on skeletal muscle mRNA expression.

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