Unknown,Transcriptomics,Genomics,Proteomics

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Muscle unloading and reloading


ABSTRACT: Examination of effect of mechanical loading induced by hindlimb suspension, and subsequent reloading, in soleus muscle in 14 day old female pathogen–free Wistar rats. Keywords = skeletal muscle Keywords = atrophy

ORGANISM(S): Rattus norvegicus

SUBMITTER: Silvia Schmutz 

PROVIDER: E-GEOD-673 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Transcriptional reprogramming during reloading of atrophied rat soleus muscle.

Flück Martin M   Schmutz Silvia S   Wittwer Matthias M   Hoppeler Hans H   Desplanches Dominique D  

American journal of physiology. Regulatory, integrative and comparative physiology 20050701 1


The hypothesis was tested that differential, coregulated transcriptional adaptations of various cellular pathways would occur early with increased mechanical loading of atrophied skeletal muscle and relate to concurrent damage of muscle fibers. Atrophy and slow-to-fast fiber transformation of rat soleus muscle was provoked by 14 days of hindlimb suspension (HS). Subsequent reloading of hindlimbs caused a fourfold increase in the percentage of muscle fibers, demonstrating endomysial tenascin-C st  ...[more]

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