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Muscle unloading and reloading

ABSTRACT: Examination of effect of mechanical loading induced by hindlimb suspension, and subsequent reloading, in soleus muscle in 14 day old female pathogenâfree Wistar rats. Keywords = skeletal muscle Keywords = atrophy

ORGANISM(S): Rattus norvegicus

SUBMITTER: Silvia Schmutz

PROVIDER: E-GEOD-673 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Transcriptional reprogramming during reloading of atrophied rat soleus muscle.

Flück Martin M Schmutz Silvia S Wittwer Matthias M Hoppeler Hans H Desplanches Dominique D

American journal of physiology. Regulatory, integrative and comparative physiology 20050701 1

The hypothesis was tested that differential, coregulated transcriptional adaptations of various cellular pathways would occur early with increased mechanical loading of atrophied skeletal muscle and relate to concurrent damage of muscle fibers. Atrophy and slow-to-fast fiber transformation of rat soleus muscle was provoked by 14 days of hindlimb suspension (HS). Subsequent reloading of hindlimbs caused a fourfold increase in the percentage of muscle fibers, demonstrating endomysial tenascin-C st ...[more]

PMID: 15956763

Similar Datasets

Muscle unloading and reloading

Project description:Examination of effect of mechanical loading induced by hindlimb suspension, and subsequent reloading, in soleus muscle in 14 day old female pathogen–free Wistar rats. Keywords = skeletal muscle Keywords = atrophy Keywords: other

2003-12-16 | GSE673 | GEO

Analysis of skeletal muscle gene expression upon mouse hindlimb unloading and reloading

Project description:To investigate the molecular mechanisms governing the transition of skeletal muscle from atrophy to compensatory regeneration and hypertrophy, we employed a mouse model involving hindlimb unloading and subsequent reloading, conducting a comprehensive analysis of global gene expression using RNA-sequencing (RNA-seq). Gastrocnemius muscle samples were obtained from three groups: control mice, mice subjected to 10 days of hindlimb unloading-induced muscle atrophy, and mice reintroduced to normal cage activity for 1 day following the unloading period (reloading).

2023-07-16 | GSE237099 | GEO

Hindlimb suspension and reloading study

Project description:Analysis of effect of hindlimb suspension and reloading on C57Bl/6 mouse soleus muscle. Experimental groups examined: -Control mice, 14 days -Hindlimb suspension for 7 days -Hindlimb suspension for 7 days, and subsequent reloading for 1 day -Hindlimb suspension for 7 days, and subsequent reloading for 7 days Keywords: other

2004-09-30 | GSE1293 | GEO

Hindlimb suspension and reloading study

2010-06-05 | E-GEOD-1293 | biostudies-arrayexpress

HS-R5

Project description:14 days hindlimb suspended, 5 days reloaded m. soleus RNA was isolated from cryosections using RNeasy kit (Qiagen). 5 microgram total RNA was subjected to microarray analysis.

2010-06-06 | E-GEOD-1084 | biostudies-arrayexpress

Functional unloading leads to metabolic and functional disorders in FAPs in vitro

Project description:In our study, we used hindlimb unloading rat model to study fibro-adipogenic progenitor cells (FAPs) condition in muscle atrophy. We have purified FAPs from m. soleus from control rats and after 7 and 14 days of immobilization (HS7, HS14). Also, we performed adipogenic differentiation of FAPS in vitro during 3 days.

2023-04-10 | GSE228869 | GEO

Transcriptome of reloaded soleus muscle of 129/SV mice

Project description:1 year-old male 129/SV mice. Animals were acclimatized to housing in single cages for one week followed by 7 days of hindlimb suspension and one day of reloading. Soleus muscle was harvested, total RNA isolated and subjected to transcript profiling with custom microarrays with custom-designed ATLASTM cDNA nylon filter as described (Dapp, C., Schmutz, S., Hoppeler, H. & Fluck, M. (2004) Physiol Genomics 20, 97-107). Keywords: transcriptome Six biological replicas

2010-06-25 | E-GEOD-8549 | biostudies-arrayexpress

Transcriptome of reloaded soleus muscle of 129/SV mice

2008-08-08 | GSE8549 | GEO

RNA-sequencing of soleus muscle from Mustn1 heterozygous KO-first mice and wildtype littermates

Project description:To uncover novel genes and molecular pathways important for skeletal muscle remodeling and regeneration, we used a mouse hindlimb unloading and reloading protocol. We then performed analysis of global gene expression by RNA-sequencing (RNA-seq), looking at the transition from muscle unloading to reloading (GSE237099). This study focuses on the microprotein Mustn1 (Musculoskeletal embryonic nuclear protein 1, also known as Mustang), which consists of 82 amino acids. We performed RNA-sequencing of soleus muscle from 8-week-old mice carrying one allele (heterozygous) of Mustn1 tm1a (KO-first) and wildtype littermates.

2024-03-14 | GSE250506 | GEO

Skeletal muscle unloading affects muscle progenitor cells functional activity

Project description:In this work we employed classic skeletal muscle unloading rat model to determine how hindlimb suspension (HS) affects functional activity of skeletal muscle progenitor cells (SMPC). We have purified SMPC from m. soleus from control rats and after 1, 3, 7 and 14 days of exposure (HS1, HS3, HS7, HS14).

2022-04-25 | GSE201281 | GEO

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