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A Novel Neuron-specific Histone H4K20 Demethylase LSD1n Promotes Transcriptional Elongation and is Essential for Learning and Memory

ABSTRACT: LSD1n regulates transcriptional elongation by removing H4K20 methylation. Identification of genome-wide binding sites of LSD1, and examination of the histone modifications upon LSD1n deletion in primary cortical neurons

ORGANISM(S): Mus musculus

SUBMITTER: Yuliang Tan

PROVIDER: E-GEOD-63271 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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LSD1n is an H4K20 demethylase regulating memory formation via transcriptional elongation control.

Wang Jianxun J Telese Francesca F Tan Yuliang Y Li Wenbo W Jin Chunyu C He Xin X Basnet Harihar H Ma Qi Q Merkurjev Daria D Zhu Xiaoyan X Liu Zhijie Z Zhang Jie J Ohgi Kenny K Taylor Havilah H White Ryan R RR Tazearslan Cagdas C Suh Yousin Y Macfarlan Todd S TS Pfaff Samuel L SL Rosenfeld Michael G MG

Nature neuroscience 20150727 9

We found that a neuron-specific isoform of LSD1, LSD1n, which results from an alternative splicing event, acquires a new substrate specificity, targeting histone H4 Lys20 methylation, both in vitro and in vivo. Selective genetic ablation of LSD1n led to deficits in spatial learning and memory, revealing the functional importance of LSD1n in neuronal activity-regulated transcription that is necessary for long-term memory formation. LSD1n occupied neuronal gene enhancers, promoters and transcribed ...[more]

PMID: 26214369

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