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Unknown,Transcriptomics,Genomics,Proteomics

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ATAC-seq in control compared to ZEB1 knock-down MDA-MB-231 cells

ABSTRACT: Identification of open chromatin regions in wildtpye, control knock-down (shCtrl) and ZEB1 knock-down (shZEB1) human breast cancer MDA-MB-231 cells by ATAC(Assay for transposable-accessible chromatin)-seq.

INSTRUMENT(S): Illumina HiSeq 2500

ORGANISM(S): Homo sapiens

SUBMITTER: Thomas Brabletz

PROVIDER: E-MTAB-8264 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Genome-wide cooperation of EMT transcription factor ZEB1 with YAP and AP-1 in breast cancer.

Feldker Nora N Ferrazzi Fulvia F Schuhwerk Harald H Widholz Sebastian A SA Guenther Kerstin K Frisch Isabell I Jakob Kathrin K Kleemann Julia J Riegel Dania D Bönisch Ulrike U Lukassen Sören S Eccles Rebecca L RL Schmidl Christian C Stemmler Marc P MP Brabletz Thomas T Brabletz Simone S

The EMBO journal 20200721 17

Invasion, metastasis and therapy resistance are the major cause of cancer-associated deaths, and the EMT-inducing transcription factor ZEB1 is a crucial stimulator of these processes. While work on ZEB1 has mainly focused on its role as a transcriptional repressor, it can also act as a transcriptional activator. To further understand these two modes of action, we performed a genome-wide ZEB1 binding study in triple-negative breast cancer cells. We identified ZEB1 as a novel interactor of the AP- ...[more]

PMID: 32692442

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