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A comprehensive epigenome map of Plasmodium falciparum reveals unique mechanisms of transcriptional regulation

ABSTRACT: Epigenetic mechanisms have been poorly understood in Plasmodium falciparum, the causative agent of malaria. To elucidate stage specific epigenetic regulations in P. falciparum, we performed genome-wide mapping of various histone modifications, nucleosomes and RNA Polymerase II. Our comprehensive analysis suggest that transcription initiation and elongation are distinct in Plasmodium. In this study, by analyzing histone modifications, nucleosome occupancy and RNA Polymerase II (Pol II) at three different IEC developmental stages of Plasmodium; ring, trophozoite and schizont, we tried to unravel the epigenetic mechanism associated with gene regulation. Examination of H3K27me3, H3K4me3, H3K9me3, H3K14ac, H3K4me1, H3K79me3, H3K27ac, H3K4me2, H3K9ac, H4ac, RNA Pol II and Histone H3 at three different stages of Plasmodium falciparum

ORGANISM(S): Plasmodium falciparum

SUBMITTER: Krishanpal Karmodiya 

PROVIDER: E-GEOD-63369 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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A comprehensive epigenome map of Plasmodium falciparum reveals unique mechanisms of transcriptional regulation and identifies H3K36me2 as a global mark of gene suppression.

Karmodiya Krishanpal K   Pradhan Saurabh J SJ   Joshi Bhagyashree B   Jangid Rahul R   Reddy Puli Chandramouli PC   Galande Sanjeev S  

Epigenetics & chromatin 20150917

<h4>Background</h4>Role of epigenetic mechanisms towards regulation of the complex life cycle/pathogenesis of Plasmodium falciparum, the causative agent of malaria, has been poorly understood. To elucidate stage-specific epigenetic regulation, we performed genome-wide mapping of multiple histone modifications of P. falciparum. Further to understand the differences in transcription regulation in P. falciparum and its host, human, we compared their histone modification profiles.<h4>Results</h4>Our  ...[more]

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