Proteomics

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Histone post-translational modification during Plasmodium falciparum gametocyte development


ABSTRACT: Histone post-translational modifications (PTMs) play an essential role in epigenetic gene regulation. The Plasmodium falciparum genome encodes canonical and variant histones and a collection of conserved enzymes for histone PTMs and chromatin remodeling. Herein, we characterized the P. falciparum histone PTMs during the development of gametocytes, the obligatory for parasite transmission, we extracted histones from the early (day 4), middle (day 8), and late (day 12) stages of gametocytes, and analyzed them by advanced mass spectrometry.

INSTRUMENT(S): Q Exactive Plus

ORGANISM(S): Plasmodium Falciparum (isolate 3d7)

TISSUE(S): Single Nucleate Cell

DISEASE(S): Plasmodium Falciparum Malaria

SUBMITTER: JUN MIAO  

LAB HEAD: Jun Miao

PROVIDER: PXD031817 | Pride | 2022-09-14

REPOSITORIES: Pride

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Publications

Distinct Histone Post-translational Modifications during <i>Plasmodium falciparum</i> Gametocyte Development.

Shrestha Sony S   Lucky Amuza Byaruhanga AB   Brashear Awtum Marie AM   Li Xiaolian X   Cui Liwang L   Miao Jun J  

Journal of proteome research 20220630 8


Histones are the building units of nucleosomes, which constitute chromatin. Histone post-translational modifications (PTMs) play an essential role in epigenetic gene regulation. The <i>Plasmodium falciparum</i> genome encodes canonical and variant histones and a collection of conserved enzymes for histone PTMs and chromatin remodeling. Herein, we profiled the <i>P. falciparum</i> histone PTMs during the development of gametocytes, the obligatory stage for parasite transmission. Mass spectrometri  ...[more]

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