Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Lin De-Chen
PROVIDER: E-GEOD-63381 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Nature genetics 20140622 8
Nasopharyngeal carcinoma (NPC) has extremely skewed ethnic and geographic distributions, is poorly understood at the genetic level and is in need of effective therapeutic approaches. Here we determined the mutational landscape of 128 cases with NPC using whole-exome and targeted deep sequencing, as well as SNP array analysis. These approaches revealed a distinct mutational signature and nine significantly mutated genes, many of which have not been implicated previously in NPC. Notably, integrate ...[more]