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Muscle - atypical diabetes protein expression

ABSTRACT: Skeletal muscle biopsies from atypical diabetics at presentation and remission. Protein expression determined with antibody arrays

ORGANISM(S): Homo sapiens

SUBMITTER: Donald Thomason

PROVIDER: E-GEOD-634 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Impaired expression and insulin-stimulated phosphorylation of Akt-2 in muscle of obese patients with atypical diabetes.

Gosmanov Aidar R AR Umpierrez Guillermo E GE Karabell Ana H AH Cuervo Ruben R Thomason Donald B DB

American journal of physiology. Endocrinology and metabolism 20040309 1

Although a pharmacological dose of insulin produces a dramatic increase in phosphorylation and activity of Akt isoforms 1 and 2 in mammalian skeletal muscle, few studies have examined the effect of physiological concentrations of insulin on the phosphorylation of Akt-1 and -2 in normal and diabetic tissue. This study examined the patterns of insulin-stimulated Akt isoform phosphorylation and protein expression in muscle biopsies obtained from obese patients with atypical diabetes immediately aft ...[more]

PMID: 15010337

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