Ontology highlight
ABSTRACT:
ORGANISM(S): Danio rerio
SUBMITTER: Deborah Stenkamp
PROVIDER: E-GEOD-63873 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Mitchell Diana M DM Stevens Craig B CB Frey Ruth A RA Hunter Samuel S SS Ashino Ryuichi R Kawamura Shoji S Stenkamp Deborah L DL
PLoS genetics 20150821 8
The signaling molecule retinoic acid (RA) regulates rod and cone photoreceptor fate, differentiation, and survival. Here we elucidate the role of RA in differential regulation of the tandemly-duplicated long wavelength-sensitive (LWS) cone opsin genes. Zebrafish embryos were treated with RA from 48 hours post-fertilization (hpf) to 75 hpf, and RNA was isolated from eyes for microarray analysis. ~170 genes showed significantly altered expression, including several transcription factors and compon ...[more]