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Microarray analysis of Wild-type vs. Brpf1-deficient P4 mouse brain

ABSTRACT: RNA was isolated from three pairs of wild-type and Brpf1-deficient mouse brains (the dorsal cortex part) at postnatal day 4 for microarray analysis. The cDNA samples were then labeled and mixed for hybridization with one array. The data from three arrays were obtained and used for bioinformatic analysis.

ORGANISM(S): Mus musculus

SUBMITTER: Xiang-Jiao Yang

PROVIDER: E-GEOD-63909 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Deficiency of the chromatin regulator BRPF1 causes abnormal brain development.

You Linya L Zou Jinfeng J Zhao Hong H Bertos Nicholas R NR Park Morag M Wang Edwin E Yang Xiang-Jiao XJ

The Journal of biological chemistry 20150107 11

Epigenetic mechanisms are important in different neurological disorders, and one such mechanism is histone acetylation. The multivalent chromatin regulator BRPF1 (bromodomain- and plant homeodomain-linked (PHD) zinc finger-containing protein 1) recognizes different epigenetic marks and activates three histone acetyltransferases, so it is both a reader and a co-writer of the epigenetic language. The three histone acetyltransferases are MOZ, MORF, and HBO1, which are also known as lysine acetyltra ...[more]

PMID: 25568313

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Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

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