Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

Expression data from pancreatic beta cells isolated from differentially weaned mice.

ABSTRACT: Transcriptome analysis reveals that in pancreatic beta cells weaning increases the expression of genes involved in replication licensing, suggesting a mechanism to increased responsiveness to the mitogenic activity of high glucose. ? cells were sorted from dissociated islets of P25 insulin-Cre; Rosa26-LSL-YFP mice (Gannon et al., 2000; Srinivas et al., 2001) that were either suckling or prematurely weaned at P18. YFP+ FACS-sorted cells were subjected for RNA extraction and hybridization on Affymetrix microarrays

ORGANISM(S): Mus musculus

SUBMITTER: Miri Stolovich-Rain

PROVIDER: E-GEOD-64524 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Weaning triggers a maturation step of pancreatic β cells.

Stolovich-Rain Miri M Enk Jonatan J Vikesa Jonas J Nielsen Finn Cilius FC Saada Ann A Glaser Benjamin B Dor Yuval Y

Developmental cell 20150205 5

Because tissue regeneration deteriorates with age, it is generally assumed that the younger the animal, the better it compensates for tissue damage. We have examined the effect of young age on compensatory proliferation of pancreatic β cells in vivo. Surprisingly, β cells in suckling mice fail to enter the cell division cycle in response to a diabetogenic injury or increased glycolysis. The potential of β cells for compensatory proliferation is acquired following premature weaning to normal chow ...[more]

PMID: 25662175

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Dataset Information

Expression data from pancreatic beta cells isolated from differentially weaned mice.

Publications

Weaning triggers a maturation step of pancreatic β cells.

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