Unknown,Transcriptomics,Genomics,Proteomics

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Blood transcriptomes of chronic HCV patients four years after therapy-induced viral clearance


ABSTRACT: Little is known on the immune status in liver and blood of chronic HCV patients long after therapy-induced viral clearance. In this study, we demonstrate that 4 years after clearance, regulation of HCV-specific immunity in blood by regulatory T-cells (Treg) and the immunosuppressive cytokines IL-10 and TGF-β is still ongoing. Importantly, sampling of the liver 4 years after clearance shows that intrahepatic Treg are still present in all patients, suggesting that liver T-cells remain regulated. Identifying mechanisms that regulate HCV-specific memory T-cell responses after clearance is highly relevant for the development of protective vaccines, especially in patients at high-risk of reinfection. A genome-wide gene expression analysis was performed on a blood cohort of 5 chronic HCV patients. For each patient, blood was collected at 4 years after ending of HCV therapy, and blood transcriptomes was compared to the paired transcriptomes at baseline and 24 weeks after ending HCV therapy (GSE59312).

ORGANISM(S): Homo sapiens

SUBMITTER: Andre Boonstra 

PROVIDER: E-GEOD-64603 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

The Intrahepatic T Cell Compartment Does Not Normalize Years After Therapy-Induced Hepatitis C Virus Eradication.

Spaan Michelle M   Claassen Mark A A MA   Hou Jun J   Janssen Harry L A HL   de Knegt Robert J RJ   Boonstra Andre A  

The Journal of infectious diseases 20150130 3


Little is known about the immune status in liver and blood of patients with chronic hepatitis C virus (HCV) infection long after therapy-induced viral clearance. In this study, we demonstrate that, 4 years after clearance, regulation of HCV-specific immunity in blood by regulatory T cells (Tregs) and the immunosuppressive cytokines interleukin 10 and transforming growth factor β is still ongoing. Importantly, analysis of liver specimens collected 4 years after HCV clearance shows that intrahepat  ...[more]

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