Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Andre Boonstra
PROVIDER: E-GEOD-64603 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Spaan Michelle M Claassen Mark A A MA Hou Jun J Janssen Harry L A HL de Knegt Robert J RJ Boonstra Andre A
The Journal of infectious diseases 20150130 3
Little is known about the immune status in liver and blood of patients with chronic hepatitis C virus (HCV) infection long after therapy-induced viral clearance. In this study, we demonstrate that, 4 years after clearance, regulation of HCV-specific immunity in blood by regulatory T cells (Tregs) and the immunosuppressive cytokines interleukin 10 and transforming growth factor β is still ongoing. Importantly, analysis of liver specimens collected 4 years after HCV clearance shows that intrahepat ...[more]