Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Anja Groth
PROVIDER: E-GEOD-65065 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
The EMBO journal 20151130 2
During DNA replication, thousands of replication origins are activated across the genome. Chromatin architecture contributes to origin specification and usage, yet it remains unclear which chromatin features impact on DNA replication. Here, we perform a RNAi screen for chromatin regulators implicated in replication control by measuring RPA accumulation upon replication stress. We identify six factors required for normal rates of DNA replication and characterize a function of the bromodomain and ...[more]