Unknown,Transcriptomics,Genomics,Proteomics

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Effects of the JADE-HBO1 complex on gene expression


ABSTRACT: We find that 499 genes are up-regulated and 457 are down-regulated in response to over-expression of JADE1, while 397 genes are up-regulated and 385 are down-regulated after HBO1 knock-down. For each condition - HBO1 siRNA treatment or JADE1 over-expression - two biological replicates were analyzed in duplicate.

ORGANISM(S): Homo sapiens

SUBMITTER: Eric Paquet 

PROVIDER: E-GEOD-33220 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications


Acetyltransferase complexes of the MYST family with distinct substrate specificities and functions maintain a conserved association with different ING tumor suppressor proteins. ING complexes containing the HBO1 acetylase are a major source of histone H3 and H4 acetylation in vivo and play critical roles in gene regulation and DNA replication. Here, our molecular dissection of HBO1/ING complexes unravels the protein domains required for their assembly and function. Multiple PHD finger domains pr  ...[more]

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