Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Eric Paquet
PROVIDER: E-GEOD-33220 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Molecular and cellular biology 20111205 3
Acetyltransferase complexes of the MYST family with distinct substrate specificities and functions maintain a conserved association with different ING tumor suppressor proteins. ING complexes containing the HBO1 acetylase are a major source of histone H3 and H4 acetylation in vivo and play critical roles in gene regulation and DNA replication. Here, our molecular dissection of HBO1/ING complexes unravels the protein domains required for their assembly and function. Multiple PHD finger domains pr ...[more]