Unknown,Transcriptomics,Genomics,Proteomics

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RNA-seq of Chlamydomonas reinhardtii exposed to inorganic or methylmercury


ABSTRACT: This study aims at investigating the link between internalized inorganic or methyl Hg and the global expression of genes, obtained by high-throughput sequencing (RNA-Seq), in the microalga Chlamydomonas reinhardtii. Algal cells were exposed two hours in a simplified artificial medium spiked with series of inorganic Hg concentrations (0.1, 1, 100 nM Hg) or series of methyl Hg concentrations (0.05, 0.5, 5, 50 nM CH3Hg). Three biological replicates were assessed for each of the 8 tested conditions: Control, 3 Hg concentrations, 4 CH3Hg concentrations.

ORGANISM(S): Chlamydomonas reinhardtii

SUBMITTER: Rebecca Beauvais-Flueck 

PROVIDER: E-GEOD-65109 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Cellular toxicity pathways of inorganic and methyl mercury in the green microalga Chlamydomonas reinhardtii.

Beauvais-Flück Rebecca R   Slaveykova Vera I VI   Cosio Claudia C  

Scientific reports 20170814 1


Contamination by mercury (Hg) is a worldwide concern because of Hg toxicity and biomagnification in aquatic food webs. Nevertheless, bioavailability and cellular toxicity pathways of inorganic (IHg) and methyl-Hg (MeHg) remain poorly understood. We analyzed the uptake, transcriptomic, and physiological responses in the microalga Chlamydomonas reinhardtii exposed to IHg or MeHg. Bioavailability of MeHg was up to 27× higher than for IHg. Genes involved in cell processes, energy metabolism and tran  ...[more]

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