Conserved epigenomic signatures between mouse and human elucidate immune basis of Alzheimer's disease

ABSTRACT: Alzheimer’s disease (AD) is a severe1 age-related neurodegenerative disorder characterized by accumulation of beta-amyloid (Aβ) plaques and neurofibrillary tangles, synaptic and neuronal loss, and cognitive decline. Several genes have been implicated in AD, but chromatin state alterations during neurodegeneration remain uncharacterized. Here, we profile transcriptional and chromatin state dynamics across early and late pathology in the hippocampus of an inducible mouse model of AD-like neurodegeneration. We find a coordinated downregulation of synaptic plasticity genes and regulatory regions, and upregulation of immune response genes and regulatory regions, which are targeted by factors that belong to the ETS family of transcriptional regulators, including PU.1. Human regions orthologo

ORGANISM(S): Mus musculus

SUBMITTER: Andreas Pfenning 

PROVIDER: E-GEOD-65159 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress