Differential expression between Sh2b3 knockout and wild type mice
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Daniel Levy
PROVIDER: E-GEOD-65348 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Integrative network analysis reveals molecular mechanisms of blood pressure regulation.
Huan Tianxiao T Meng Qingying Q Saleh Mohamed A MA Norlander Allison E AE Joehanes Roby R Zhu Jun J Chen Brian H BH Zhang Bin B Johnson Andrew D AD Ying Saixia S Courchesne Paul P Raghavachari Nalini N Wang Richard R Liu Poching P O'Donnell Christopher J CJ Vasan Ramachandran R Munson Peter J PJ Madhur Meena S MS Harrison David G DG Yang Xia X Levy Daniel D
Molecular systems biology 20150416 1
Genome-wide association studies (GWAS) have identified numerous loci associated with blood pressure (BP). The molecular mechanisms underlying BP regulation, however, remain unclear. We investigated BP-associated molecular mechanisms by integrating BP GWAS with whole blood mRNA expression profiles in 3,679 individuals, using network approaches. BP transcriptomic signatures at the single-gene and the coexpression network module levels were identified. Four coexpression modules were identified as p ...[more]
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