Ontology highlight
ABSTRACT:
ORGANISM(S): Pseudomonas aeruginosa
SUBMITTER: Xin Deng
PROVIDER: E-GEOD-65356 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Kong Weina W Zhao Jingru J Kang Huaping H Zhu Miao M Zhou Tianhong T Deng Xin X Liang Haihua H
Nucleic acids research 20150722 17
AlgR is a key transcriptional regulator required for the expression of multiple virulence factors, including type IV pili and alginate in Pseudomonas aeruginosa. However, the regulon and molecular regulatory mechanism of AlgR have yet to be fully elucidated. Here, among 157 loci that were identified by a ChIP-seq assay, we characterized a gene, mucR, which encodes an enzyme that synthesizes the intracellular second messenger cyclic diguanylate (c-di-GMP). A ΔalgR strain produced lesser biofilm t ...[more]