Genetic disruption of COX-1 inhibits multiple oncogenic pathways
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Dineo Khabele
PROVIDER: E-GEOD-66173 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Aberrant over-expression of COX-1 intersects multiple pro-tumorigenic pathways in high-grade serous ovarian cancer.
Wilson Andrew J AJ Fadare Oluwole O Beeghly-Fadiel Alicia A Son Deok-Soo DS Liu Qi Q Zhao Shilin S Saskowski Jeanette J Uddin Md Jashim MJ Daniel Cristina C Crews Brenda B Lehmann Brian D BD Pietenpol Jennifer A JA Crispens Marta A MA Marnett Lawrence J LJ Khabele Dineo D
Oncotarget 20150801 25
Cyclooxygenase-1 (COX-1) is implicated in ovarian cancer. However, patterns of COX expression and function have been unclear and controversial. In this report, patterns of COX-1 and COX-2 gene expression were obtained from RNA-seq data through The Cancer Genome Atlas. Our analysis revealed markedly higher COX-1 mRNA expression than COX-2 in high-grade serous ovarian cancers (HGSOC) and higher COX-1 expression in HGSOC tumors than 10 other tumor types. High expression of COX-1 in HGSOC tumors was ...[more]
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