Ontology highlight
ABSTRACT:
ORGANISM(S): Drosophila melanogaster
SUBMITTER: Peter Park
PROVIDER: E-GEOD-66183 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Kang Hyuckjoon H McElroy Kyle A KA Jung Youngsook Lucy YL Alekseyenko Artyom A AA Zee Barry M BM Park Peter J PJ Kuroda Mitzi I MI
Genes & development 20150601 11
The Polycomb group (PcG) proteins are key regulators of development in Drosophila and are strongly implicated in human health and disease. How PcG complexes form repressive chromatin domains remains unclear. Using cross-linked affinity purifications of BioTAP-Polycomb (Pc) or BioTAP-Enhancer of zeste [E(z)], we captured all PcG-repressive complex 1 (PRC1) or PRC2 core components and Sex comb on midleg (Scm) as the only protein strongly enriched with both complexes. Although previously not linked ...[more]