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EphB2 promotes progression of cutaneous squamous cell carcinoma

ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Homo sapiens

SUBMITTER: Liisa Nissinen

PROVIDER: E-GEOD-66368 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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EphB2 Promotes Progression of Cutaneous Squamous Cell Carcinoma.

Farshchian Mehdi M Nissinen Liisa L Siljamäki Elina E Riihilä Pilvi P Toriseva Mervi M Kivisaari Atte A Ala-Aho Risto R Kallajoki Markku M Veräjänkorva Esko E Honkanen Hanne-Kaisa HK Heljasvaara Ritva R Pihlajaniemi Taina T Grénman Reidar R Peltonen Juha J Peltonen Sirkku S Kähäri Veli-Matti VM

The Journal of investigative dermatology 20150319 7

Keratinocyte-derived skin cancer, cutaneous squamous cell carcinoma (cSCC), is the most common metastatic skin cancer. We have examined the role of Eph/ephrin signaling in the progression of cSCC. Analysis of the expression of EPH and EFN families in cSCC cells and normal epidermal keratinocytes revealed overexpression of EPHB2 mRNA in cSCC cells and cSCC tumors in vivo. Tumor cell-specific overexpression of EphB2 was detected in human cSCCs and in chemically induced mouse cSCCs with immunohisto ...[more]

PMID: 25789706

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Analysis of the gene expression profile in cutaneous squamous cell carcinoma cells after EphB2 knockdown

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2015-08-27 | E-GEOD-66361 | biostudies-arrayexpress

Analysis of the gene expression profile in normal human epidermal keratinocytes and cutaneous squamous cell carcinoma cell lines

Project description:The incidence of keratinocyte-derived skin cancer, cutaneous squamous cell carcinoma (cSCC) is increasing worldwide making it the second most common metastatic skin cancer. We used microarrays to characterize gene expression profile in normal human epidermal keratinocytes (NHEK) and cSCC cell lines. Total RNAs from normal human epidermal keratinocytes (n=5) and cSCC cell lines (n=8) were extracted. The samples were processed for Affymetrix 3´ IVT Express Kit according to manufacture’s protocol.

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The effects of muscular dystrophy, exercise and sActRIIB-Fc on molecular signature of skeletal muscle in mice

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Expression data from leaf tissues of 35S:AtHMA4 and wild-type tomato plants grown in the presence of Zn

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2015-05-08 | E-GEOD-68640 | biostudies-arrayexpress

35S:AtHMA4 and wild-type tomato plants grown in the presence of Zn

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

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2015-05-08 | E-GEOD-68639 | biostudies-arrayexpress

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