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The novel atypical retinoid ST5589 down-regulates Aurora Kinase A and has anti-tumour activity in lymphoma pre-clinical models

ABSTRACT: we report characterized the preclinical activity of a new member of this class, the ST1926-derivative ST5589, in lymphomas GEP analysis of 2 lymphoma cell lines with and without treatment

ORGANISM(S): Homo sapiens

SUBMITTER: Francesco Bertoni

PROVIDER: E-GEOD-66455 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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The novel atypical retinoid ST5589 down-regulates Aurora Kinase A and has anti-tumour activity in lymphoma pre-clinical models.

Bernasconi Elena E Gaudio Eugenio E Kwee Ivo I Rinaldi Andrea A Cascione Luciano L Tarantelli Chiara C Mensah Afua Adjeiwaa AA Stathis Anastasios A Zucca Emanuele E Vesci Loredana L Giannini Giuseppe G Bertoni Francesco F

British journal of haematology 20150803 3

Despite the marked improvements in the treatment of lymphomas, there is still a need for new therapeutic agents. Synthetic retinoids represent a class of compounds with anti-cancer activity. Here, we report the preclinical activity of a new member of this class, the ST1926-derivative ST5589, in lymphomas. ST5589 presented a dose-dependent anti-proliferative activity in almost all of the 25 lymphoma cell lines analysed, with a median 50% inhibitory concentration of 433 nM. Apoptosis was observed ...[more]

PMID: 26235926

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