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Epigenomic landscapes of human inflammation associated macrophages

ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Homo sapiens

SUBMITTER: Joachim Schultze

PROVIDER: E-GEOD-66595 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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The transcriptional regulator network of human inflammatory macrophages is defined by open chromatin.

Schmidt Susanne V SV Krebs Wolfgang W Ulas Thomas T Xue Jia J Baßler Kevin K Günther Patrick P Hardt Anna-Lena AL Schultze Hartmut H Sander Jil J Klee Kathrin K Theis Heidi H Kraut Michael M Beyer Marc M Schultze Joachim L JL

Cell research 20160105 2

Differentiation of inflammatory macrophages from monocytes is characterized by an orderly integration of epigenetic and transcriptional regulatory mechanisms guided by lineage-determining transcription factors such as PU.1. Further activation of macrophages leads to a stimulus- or microenvironment-specific signal integration with subsequent transcriptional control established by the action of tissue- or signal-associated transcription factors. Here, we assess four histone modifications during hu ...[more]

PMID: 26729620

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