Dataset Information

Effects of Triclosan and its alternatives on LPS-stimulated THP-1 macrophages

ABSTRACT: In this study, the effects of Triclosan (TCS) and its alternatives, including Benzalkonium chloride (BAM), Benzethonium chloride (BEC), Chloroxylenol (CEO), Chlorhexidine (CHX) and Cetylpyridinium chloride (CPC), were investigated in THP-1 macrophages. For this purpose, untargeted proteomics was applied.

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Monocyte, Cell Culture, Macrophage

SUBMITTER: Stefanie Raps

LAB HEAD: Kristin Schubert

PROVIDER: PXD044828 | Pride | 2024-02-05

REPOSITORIES: Pride

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Dataset's files

Source:

			Action	DRS
	20220304_uniprot_homo_sapiens_Refset_SR.fasta	Fasta
	20220719_TCS_and_Alternatives.msf	Msf
	20220719_TCS_and_Alternatives.mzML	Mzml
	20220719_TCS_and_Alternatives.mzid.gz	Mzid
	20220719_TCS_and_Alternatives_QuanSpectra.txt	Txt

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Publications

Triclosan and its alternatives, especially chlorhexidine, modulate macrophage immune response with distinct modes of action.

Raps Stefanie S Bahr Laura L Karkossa Isabel I Rossol Manuela M von Bergen Martin M Schubert Kristin K

The Science of the total environment 20231229

Since European regulators restricted the use of bacteriocidic triclosan (TCS), alternatives for TCS are emerging. Recently, TCS has been shown to reprogram immune metabolism, trigger the NLRP3 inflammasome, and subsequently the release of IL-1β in human macrophages, but data on substitutes is scarce. Hence, we aimed to examine the effects of TCS compared to its alternatives at the molecular level in human macrophages. LPS-stimulated THP-1 macrophages were exposed to TCS or its substitutes, inclu ...[more]

PMID: 38159774

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