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Hepatocyte-specific knockout of Pten and of Pten and Tgfbr2 in mice

ABSTRACT: Gene expression of hepatocyt-specific knockout of Pten and of Pten and Tgfbr2 in mice as a model for human cholangiocarcinoma was determined Affymetrix Mouse 1.0ST chips were used to measure gene expression Gene expression of the following mouse livers were characterized A. WT (n=3). B. Pten-/- (n=4). C. Pten-/- Tgfbr2-/- (n=4).

ORGANISM(S): Mus musculus

SUBMITTER: Robert Schwabe

PROVIDER: E-GEOD-66717 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Epithelial Transforming Growth Factor-β Signaling Does Not Contribute to Liver Fibrosis but Protects Mice From Cholangiocarcinoma.

Mu Xueru X Pradere Jean-Philippe JP Affò Silvia S Dapito Dianne H DH Friedman Richard R Lefkovitch Jay H JH Schwabe Robert F RF

Gastroenterology 20151126 3

<h4>Background & aims</h4>Transforming growth factor-β (TGFβ) exerts key functions in fibrogenic cells, promoting fibrosis development in the liver and other organs. In contrast, the functions of TGFβ in liver epithelial cells are not well understood, despite their high level of responsiveness to TGFβ. We sought to determine the contribution of epithelial TGFβ signaling to hepatic fibrogenesis and carcinogenesis.<h4>Methods</h4>TGFβ signaling in liver epithelial cells was inhibited by albumin-Cr ...[more]

PMID: 26627606

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2011-10-27 | E-GEOD-32309 | biostudies-arrayexpress

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GATA4

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2013-11-07 | E-GEOD-49132 | biostudies-arrayexpress

Subtle variations in Pten dose determine cancer susceptibility: Gene expression profiling of a Ptenhy/+ mouse model

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