Identification of mir-342-3p functionally associated with transcriptional activity of MYC in lung cancer [cell culture]

ABSTRACT: Accumulating evidence indicates that altered miRNA expression is crucially involved in lung cancer development, but only little has been elucidated about how MYC, an archetypical oncogene, is regulated by miRNAs, especially through a mechanism involving the MYC cofactor(s). In this study, we aimed at identifying miRNAs involved in the regulation of MYC transcriptional activity in lung cancers. To this end, we have taken an integrative approach with combinatorial usage of miRNA and mRNA expression profile datasets of patientsâ?? tumor tissues as well as those of MYC-inducible cell lines in vitro. We report here that in addition to miRNAs previously reported to be directly regulating or regulated by MYC including let-7 and miR-17-92, our strategy allowed us to identify miR-342-3p as the one

ORGANISM(S): Homo sapiens

SUBMITTER: Takashi Takahashi 

PROVIDER: E-GEOD-66758 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress