Unknown,Transcriptomics,Genomics,Proteomics

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RNA-seq analysis of gene expression patterns responding to TSA treatment during hESC neural differentiation


ABSTRACT: We report the differential roles of an HDAC inhibitor-TSA during hESC nerual commitment. In the initiation of hESC differentiation, TSA could inhibit the downregulation of pluripotency genes to maintain pluripotency, whereas in the neural commitment stage, TSA could promote neural gene expression to assist hESC nerual determination. Examination of gene expression patterns in hESCs, day 4 or day 8 differentiated cells without or with TSA treatment

ORGANISM(S): Homo sapiens

SUBMITTER: Naihe Jing 

PROVIDER: E-GEOD-66777 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Dual roles of histone H3 lysine 9 acetylation in human embryonic stem cell pluripotency and neural differentiation.

Qiao Yunbo Y   Wang Ran R   Yang Xianfa X   Tang Ke K   Jing Naihe N  

The Journal of biological chemistry 20141217 4


Early neurodevelopment requires cell fate commitment from pluripotent stem cells to restricted neural lineages, which involves the epigenetic regulation of chromatin structure and lineage-specific gene transcription. However, it remains unclear how histone H3 lysine 9 acetylation (H3K9Ac), an epigenetic mark representing transcriptionally active chromatin, is involved in the neural commitment from pluripotent embryonic stem cells (ESCs). In this study, we demonstrate that H3K9Ac gradually declin  ...[more]

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