Dynamics of replication-independent histone turnover in budding yeast
Ontology highlight
ABSTRACT:
ORGANISM(S): Saccharomyces cerevisiae
SUBMITTER: Tommy Kaplan
PROVIDER: E-GEOD-6680 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Dynamics of replication-independent histone turnover in budding yeast.
Dion Michael F MF Kaplan Tommy T Kim Minkyu M Buratowski Stephen S Friedman Nir N Rando Oliver J OJ
Science (New York, N.Y.) 20070301 5817
Chromatin plays roles in processes governed by different time scales. To assay the dynamic behavior of chromatin in living cells, we used genomic tiling arrays to measure histone H3 turnover in G1-arrested Saccharomyces cerevisiae at single-nucleosome resolution over 4% of the genome, and at lower (approximately 265 base pair) resolution over the entire genome. We find that nucleosomes at promoters are replaced more rapidly than at coding regions and that replacement rates over coding regions co ...[more]
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