Ontology highlight
ABSTRACT:
ORGANISM(S): Danio rerio
SUBMITTER: yadong yang
PROVIDER: E-GEOD-66860 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Biochemical and biophysical research communications 20150403 4
Our previous study on the dynamic transcriptomes activated during human erythropoiesis suggested that transcription factor forkhead box O3 (FOXO3) possibly plays a role in erythroid differentiation. Functional studies in human cell line TF-1 indicated that FOXO3 knockdown repressed erythropoietin (EPO)-induced erythroid differentiation by activating promoter region of B-cell translocation gene 1 (BTG1), thereby regulating its expression. In zebrafish, injection of foxo3b-specific morpholinos (fo ...[more]