Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: kaifu chen
PROVIDER: E-GEOD-66870 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Chen Lin L Chen Kaifu K Lavery Laura A LA Baker Steven Andrew SA Shaw Chad A CA Li Wei W Zoghbi Huda Y HY
Proceedings of the National Academy of Sciences of the United States of America 20150413 17
Epigenetic mechanisms, such as DNA methylation, regulate transcriptional programs to afford the genome flexibility in responding to developmental and environmental cues in health and disease. A prime example involving epigenetic dysfunction is the postnatal neurodevelopmental disorder Rett syndrome (RTT), which is caused by mutations in the gene encoding methyl-CpG binding protein 2 (MeCP2). Despite decades of research, it remains unclear how MeCP2 regulates transcription or why RTT features app ...[more]