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Renal cell carcinoma

ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Homo sapiens

SUBMITTER: Jeff Nie

PROVIDER: E-GEOD-66885 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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High-resolution profiling of histone h3 lysine 36 trimethylation in metastatic renal cell carcinoma.

Ho T H TH Park I Y IY Zhao H H Tong P P Champion M D MD Yan H H Monzon F A FA Hoang A A Tamboli P P Parker A S AS Joseph R W RW Qiao W W Dykema K K Tannir N M NM Castle E P EP Nunez-Nateras R R Teh B T BT Wang J J Walker C L CL Hung M-C MC Jonasch E E

Oncogene 20150615 12

Mutations in SETD2, a histone H3 lysine trimethyltransferase, have been identified in clear cell renal cell carcinoma (ccRCC); however it is unclear if loss of SETD2 function alters the genomic distribution of histone 3 lysine 36 trimethylation (H3K36me3) in ccRCC. Furthermore, published epigenomic profiles are not specific to H3K36me3 or metastatic tumors. To determine if progressive SETD2 and H3K36me3 dysregulation occurs in metastatic tumors, H3K36me3, SETD2 copy number (CN) or SETD2 mRNA abu ...[more]

PMID: 26073078

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