Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Chad Creighton
PROVIDER: E-GEOD-66963 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Molecular endocrinology (Baltimore, Md.) 20160328 5
Epigenetic silencing of steroidogenic factor 1 (SF1) is lost in endometriosis, potentially contributing to de novo local steroidogenesis favoring inflammation and growth of ectopic endometrial tissue. In this study, we examine the impact of SF1 expression in the eutopic uterus by a novel mouse model that conditionally expresses SF1 in endometrium. In vivo SF1 expression promoted the development of enlarged endometrial glands and attenuated estrogen and progesterone responsiveness. Endometriosis ...[more]