Unknown,Transcriptomics,Genomics,Proteomics

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Gene expression profiling of SF1 in mouse uterus tissues


ABSTRACT: Epigenetic silencing of Steroidogenic Factor 1 (SF1) is lost in endometrial tissue in endometriosis and this is hypothesized to result in de novo local steroidogenesis favoring growth and inflammation. The goal of this study was to evaluate the endometrial specific transcriptional and functional role of SF1 in vivo by utilizing a mouse model in which SF1 was conditionally expressed in the uterus. SF1 expression resulted in the development of cystic endometrial glands and infertility. Endometriosis induction by auto-transplantation of a biopsy of uterine tissue sutured to the mesenteric membrane resulted in 4-fold increase in size ectopic lesions from SF1 expressing mice. Microarray analysis demonstrated SF1-regulated genes are involved in several pathways including epithelial and tube development, migration of lymphocytes and leukocytes, cellular movement and vascular development. experimental group (SF-1 transgenic) and control group

ORGANISM(S): Mus musculus

SUBMITTER: Chad Creighton 

PROVIDER: E-GEOD-66963 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Endometrial Expression of Steroidogenic Factor 1 Promotes Cystic Glandular Morphogenesis.

Vasquez Yasmin M YM   Wu San-Pin SP   Anderson Matthew L ML   Hawkins Shannon M SM   Creighton Chad J CJ   Ray Madhumita M   Tsai Sophia Y SY   Tsai Ming-Jer MJ   Lydon John P JP   DeMayo Francesco J FJ  

Molecular endocrinology (Baltimore, Md.) 20160328 5


Epigenetic silencing of steroidogenic factor 1 (SF1) is lost in endometriosis, potentially contributing to de novo local steroidogenesis favoring inflammation and growth of ectopic endometrial tissue. In this study, we examine the impact of SF1 expression in the eutopic uterus by a novel mouse model that conditionally expresses SF1 in endometrium. In vivo SF1 expression promoted the development of enlarged endometrial glands and attenuated estrogen and progesterone responsiveness. Endometriosis  ...[more]

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