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Understanding the role of Shoc2 protein in spatio-temporal regulation of extracellular signal-regulated kinase (ERK1/2) cascade

ABSTRACT: This study was designed to understanding changes in RNA transcription in cells depleted of Shoc2 scaffold. 2 samples were analyzed (3 replicates for each sample were included). Cos1 is a control sample.

ORGANISM(S): Chlorocebus sabaeus

SUBMITTER: Eric Rouchka

PROVIDER: E-GEOD-67063 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Shoc2-tranduced ERK1/2 motility signals--Novel insights from functional genomics.

Jeoung Myoungkun M Jang Eun Ryoung ER Liu Jinpeng J Wang Chi C Rouchka Eric C EC Li Xiaohong X Galperin Emilia E

Cellular signalling 20160211 5

The extracellular signal-regulated kinase 1 and 2 (ERK1/2) pathway plays a central role in defining various cellular fates. Scaffold proteins modulating ERK1/2 activity control growth factor signals transduced by the pathway. Here, we analyzed signals transduced by Shoc2, a critical positive modulator of ERK1/2 activity. We found that loss of Shoc2 results in impaired cell motility and delays cell attachment. As ERKs control cellular fates by stimulating transcriptional response, we hypothesized ...[more]

PMID: 26876614

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