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Epigenome analysis of squamous cell carcinoma samples

ABSTRACT: Genome wide DNA methylation profiling of squamous cell carcinoma and location matched normal samples Bisulphite converted DNA from the 13 samples were hybridized to the Illumina Infinium 450k Human Methylation Beadchip.

ORGANISM(S): Homo sapiens

SUBMITTER: Andrew Feinberg

PROVIDER: E-GEOD-67097 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Age and sun exposure-related widespread genomic blocks of hypomethylation in nonmalignant skin.

Vandiver Amy R AR Irizarry Rafael A RA Hansen Kasper D KD Garza Luis A LA Runarsson Arni A Li Xin X Chien Anna L AL Wang Timothy S TS Leung Sherry G SG Kang Sewon S Feinberg Andrew P AP

Genome biology 20150416

<h4>Background</h4>Aging and sun exposure are the leading causes of skin cancer. It has been shown that epigenetic changes, such as DNA methylation, are well established mechanisms for cancer, and also have emerging roles in aging and common disease. Here, we directly ask whether DNA methylation is altered following skin aging and/or chronic sun exposure in humans.<h4>Results</h4>We compare epidermis and dermis of both sun-protected and sun-exposed skin derived from younger subjects (under 35 ye ...[more]

PMID: 25886480

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