Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Peng Jin
PROVIDER: E-GEOD-67188 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Miao Zhigang Z He Yuquan Y Xin Ning N Sun Miao M Chen Li L Lin Li L Li Jizhen J Kong Jiming J Jin Peng P Xu Xingshun X
Human molecular genetics 20150730 20
Epigenetic modifications such as cytosine methylation and histone modification are linked to the pathology of ischemic brain injury. Recent research has implicated 5-hydroxymethylcytosine (5hmC), a DNA base derived from 5-methylcytosine (5mC) via oxidation by ten-eleven translocation (Tet) enzymes, in DNA methylation-related plasticity. Here we show that 5hmC abundance was increased after ischemic injury, and Tet2 was responsible for this increase; furthermore, inhibiting Tet2 expression abolish ...[more]