Gene expression changes in aortas of db/db versus control db/+ mice
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Nino Mzhavia
PROVIDER: E-GEOD-6733 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Neuronatin: a new inflammation gene expressed on the aortic endothelium of diabetic mice.
Mzhavia Nino N Yu Shuiqing S Ikeda Shota S Chu Tehua T TT Goldberg Ira I Dansky Hayes M HM
Diabetes 20080630 10
<h4>Objective</h4>Identification of arterial genes and pathways altered in obesity and diabetes.<h4>Research design and methods</h4>Aortic gene expression profiles of obese and diabetic db/db, high-fat diet-fed C57BL/6J, and control mice were obtained using mouse Affymetrix arrays. Neuronatin (Nnat) was selected for further analysis. To determine the function of Nnat, a recombinant adenovirus (Ad-Nnat) was used to overexpress the Nnat gene in primary endothelial cells and in the mouse aorta in v ...[more]
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