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Gene expression changes in aortas of mice on high fat versus regular chow diet.

ABSTRACT: To determine effects of hyperglycemia and insulin resistance on arterial wall biology, gene expression profiles were generated using aortas from mice on high fat (35% fat) diet and their respective non diabetic regular chow fed controls. Keywords: Chip Experiment was done in triplicate with three independent pools from test mice on high fat diet and control mice on regular chow diet. For RNA isolation aortas were striped of adventitia and periaortic fat. RNA from three aortas was pooled for the synthesis of probe for affymetrix array analysis.

ORGANISM(S): Mus musculus

SUBMITTER: Nino Mzhavia 

PROVIDER: E-GEOD-6735 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Neuronatin: a new inflammation gene expressed on the aortic endothelium of diabetic mice.

Mzhavia Nino N   Yu Shuiqing S   Ikeda Shota S   Chu Tehua T TT   Goldberg Ira I   Dansky Hayes M HM  

Diabetes 20080630 10

<h4>Objective</h4>Identification of arterial genes and pathways altered in obesity and diabetes.<h4>Research design and methods</h4>Aortic gene expression profiles of obese and diabetic db/db, high-fat diet-fed C57BL/6J, and control mice were obtained using mouse Affymetrix arrays. Neuronatin (Nnat) was selected for further analysis. To determine the function of Nnat, a recombinant adenovirus (Ad-Nnat) was used to overexpress the Nnat gene in primary endothelial cells and in the mouse aorta in v  ...[more]

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