Unknown,Transcriptomics,Genomics,Proteomics

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Genome-wide copy number analyses reveal genomic abnormalities involved in transformation of follicular lymphoma


ABSTRACT: We studied 277 lymphoma samples (198 FL and 79 transformed FL [tFL]) using a single-nucleotide polymorphism array to identify the secondary chromosomal abnormalities that drive the development of FL and its transformation to diffuse large B-cell lymphoma. Affymetrix 250K NspI SNP arrays were performed according to the manufacturer's directions on DNA extracted from frozen follicular lymphoma or transformed follicular lymphoma tumor specimens

ORGANISM(S): Homo sapiens

SUBMITTER: Wing Chan 

PROVIDER: E-GEOD-67385 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications


Follicular lymphoma (FL), the second most common type of non-Hodgkin lymphoma in the western world, is characterized by the t(14;18) translocation, which is present in up to 90% of cases. We studied 277 lymphoma samples (198 FL and 79 transformed FL [tFL]) using a single-nucleotide polymorphism array to identify the secondary chromosomal abnormalities that drive the development of FL and its transformation to diffuse large B-cell lymphoma. Common recurrent chromosomal abnormalities in FL include  ...[more]

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