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Toward a functional annotation of the human genome using artificial transcription factors

ABSTRACT: Toward a functional annotation of the human genome using artificial transcription factors.

ORGANISM(S): Homo sapiens

SUBMITTER: Jin-Soo Kim

PROVIDER: E-GEOD-677 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Toward a functional annotation of the human genome using artificial transcription factors.

Lee Dong-ki DK Park Jin Woo JW Kim Youn-Jae YJ Kim Jiwon J Lee Yangsoon Y Kim Jeonglim J Kim Jin-Soo JS

Genome research 20031201 12

We have developed a novel, high-throughput approach to collecting randomly perturbed gene-expression profiles from the human genome.A human 293 cell library that stably expresses randomly chosen zinc-finger transcription factors was constructed, and the expression profile of each cell line was obtained using cDNA microarray technology.Gene expression profiles from a total of 132 cell lines were collected and analyzed by (1) a simple clustering method based on expression-profile similarity, and ( ...[more]

PMID: 14656973

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