Unknown,Transcriptomics,Genomics,Proteomics

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Temporal Cortex Control (Alzheimer's disease control)

ABSTRACT: Ion channel splice array data from temporal cortex brain tissue samples collected from control subjects (no Alzheimer's disease). Temporal cortex (Alzheimer's disease affected brain tissue structure) and cerebellum (Alzheimer's disease unaffected brain tissue structure) samples from control subjects were compared to temporal cortex and cerebellum of patients with Alzheimer's disease.

ORGANISM(S): Homo sapiens

SUBMITTER: Erin Heinzen 

PROVIDER: E-GEOD-6774 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Alternative ion channel splicing in mesial temporal lobe epilepsy and Alzheimer's disease.

Heinzen Erin L EL   Yoon Woohyun W   Weale Michael E ME   Sen Arjune A   Wood Nicholas W NW   Burke James R JR   Welsh-Bohmer Kathleen A KA   Hulette Christine M CM   Sisodiya Sanjay M SM   Goldstein David B DB  

Genome biology 20070101 3

<h4>Background</h4>Alternative gene transcript splicing permits a single gene to produce multiple proteins with varied functions. Bioinformatic investigations have identified numerous splice variants, but whether these transcripts are translated to functional proteins and the physiological significance of these alternative proteins are largely unknown. Through direct identification of splice variants associated with disease states, we can begin to address these questions and to elucidate their r  ...[more]

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