Transcription profiling of human HPV-positive and -negative head/neck and cervical cancers

ABSTRACT: Human papillomaviruses (HPVs) are associated with nearly all cervical cancers (CCs), 20-30% of head and neck cancers (HNCs), and other cancers. Because HNCs also arise in HPV-negative patients, this type of cancer provides unique opportunities to define similarities and differences of HPV-positive versus HPV-negative cancers arising in the same tissue. Here, we describe genome-wide expression profiling of 84 HNCs, CCs and site-matched normal epithelial samples in which we used laser capture microdissection to enrich samples for tumor-derived versus normal epithelial cells. This analysis revealed that HPV+HNCs and CCs differed in their patterns of gene expression yet shared many changes compared to HPV-HNCs. Some of these shared changes were predicted, but many others were not. Notably, H

ORGANISM(S): Homo sapiens

SUBMITTER: Paul Ahlquist 

PROVIDER: E-GEOD-6791 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress