Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

Transcription profiling of mouse tissues from strain C57BL6

ABSTRACT: Gene expression was studied from different mouse tissues Experiment Overall Design: Tissues were harvested from adult mice and processed for microarray analysis

ORGANISM(S): Mus musculus

SUBMITTER: Kevin Jon Cheung

PROVIDER: E-GEOD-6793 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Xanthine oxidoreductase is a regulator of adipogenesis and PPARgamma activity.

Cheung Kevin J KJ Tzameli Iphigenia I Pissios Pavlos P Rovira Ilsa I Gavrilova Oksana O Ohtsubo Toshio T Chen Zhu Z Finkel Toren T Flier Jeffrey S JS Friedman Jeffrey M JM

Cell metabolism 20070201 2

In an effort to identify novel candidate regulators of adipogenesis, gene profiling of differentiating 3T3-L1 preadipocytes was analyzed using a novel algorithm. We report here the characterization of xanthine oxidoreductase (XOR) as a novel regulator of adipogenesis. XOR lies downstream of C/EBPbeta and upstream of PPARgamma, in the cascade of factors that control adipogenesis, and it regulates PPARgamma activity. In vitro, knockdown of XOR inhibits adipogenesis and PPARgamma activity while con ...[more]

PMID: 17276354

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Dataset Information

Transcription profiling of mouse tissues from strain C57BL6

Publications

Xanthine oxidoreductase is a regulator of adipogenesis and PPARgamma activity.

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