Transcription profiling of adult C57BL6 mouse tissues and 3T3-L1 fibroblasts
Ontology highlight
ABSTRACT:
Note: GSM156880.CEL is not available from GEO.
ORGANISM(S): Mus musculus
SUBMITTER: Kevin Jon Cheung
PROVIDER: E-GEOD-6795 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Xanthine oxidoreductase is a regulator of adipogenesis and PPARgamma activity.
Cheung Kevin J KJ Tzameli Iphigenia I Pissios Pavlos P Rovira Ilsa I Gavrilova Oksana O Ohtsubo Toshio T Chen Zhu Z Finkel Toren T Flier Jeffrey S JS Friedman Jeffrey M JM
Cell metabolism 20070201 2
In an effort to identify novel candidate regulators of adipogenesis, gene profiling of differentiating 3T3-L1 preadipocytes was analyzed using a novel algorithm. We report here the characterization of xanthine oxidoreductase (XOR) as a novel regulator of adipogenesis. XOR lies downstream of C/EBPbeta and upstream of PPARgamma, in the cascade of factors that control adipogenesis, and it regulates PPARgamma activity. In vitro, knockdown of XOR inhibits adipogenesis and PPARgamma activity while con ...[more]
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