46,XY sex reversed females with complete androgen insensitivity syndrome
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Paul-Martin Holterhus
PROVIDER: E-GEOD-6797 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Intrinsic androgen-dependent gene expression patterns revealed by comparison of genital fibroblasts from normal males and individuals with complete and partial androgen insensitivity syndrome.
Holterhus Paul-Martin PM Deppe Uta U Werner Ralf R Richter-Unruh Annette A Bebermeier Jan-Hendrik JH Wünsch Lutz L Krege Susanne S Schweikert Hans-Udo HU Demeter Janos J Riepe Felix F Hiort Olaf O Brooks James D JD
BMC genomics 20071018
<h4>Background</h4>To better understand the molecular programs of normal and abnormal genital development, clear-cut definition of androgen-dependent gene expression patterns, without the influence of genotype (46, XX vs. 46, XY), is warranted. Previously, we have identified global gene expression profiles in genital-derived fibroblasts that differ between 46, XY males and 46, XY females with complete androgen insensitivity syndrome (CAIS) due to inactivating mutations of the androgen receptor ( ...[more]
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