Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of human bronchial airway epithelial cells infected with P. aeruginosa, S.aureus or respiratory syncytial virus vs uninfected controls to investigate the role of epithelial cells upon infection of airway pathogens

ABSTRACT: Bronchial epithelial cells represent the first line of defense against invading airborne pathogens. They are important contributors to innate mucosal immunity and provide a variety of anti-microbial effectors. To investigate the role of epithelial cells upon infection of airway pathogens, we stimulated BEAS-2B cells for 4 h with UV-inactivated bronchial pathogens including Staphylococcus aureus, Pseudomonas aeruginosa and Respiratory Syncitial Virus (RSV) that among other receptors can strongly activate TLR2, TLR4 and TLR3, respectively. Experiment Overall Design: All conditions were done in triplicates except for Staphylococcus aureus, were two replicates were done. As a control, unstimulated BEAS-2B were used. Altogether 11 arrays were hybridized.

ORGANISM(S): Homo sapiens

SUBMITTER: Joerg Mages 

PROVIDER: E-GEOD-6802 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Differential recognition of TLR-dependent microbial ligands in human bronchial epithelial cells.

Mayer Anja K AK   Muehmer Mario M   Mages Jörg J   Gueinzius Katja K   Hess Christian C   Heeg Klaus K   Bals Robert R   Lang Roland R   Dalpke Alexander H AH  

Journal of immunology (Baltimore, Md. : 1950) 20070301 5

Bronchial epithelial cells represent the first line of defense against invading airborne pathogens. They are important contributors to innate mucosal immunity and provide a variety of antimicrobial effectors. However, mucosal surfaces are prone to contact with pathogenic, as well as nonpathogenic microbes, and therefore, immune recognition principles have to be tightly controlled to avoid uncontrolled permanent activation. TLRs have been shown to recognize conserved microbial patterns and to med  ...[more]

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